Keep track of Closely (two)pentobarbital will decrease the level or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Sturdy CYP3A4 inducers may well reduce suvorexant efficacy; if elevated suvorexant dose essential, don't exceed 20 mg/daypentobarbital will lessen the level or impact of buprenorphine